This study examines long-term cognitive and neural outcomes in children who experienced cardiorespiratory arrest, finding specific cognitive impairments and structural brain abnormalities.

Developmental Science · Apr 1, 2024Peer-reviewedNeuroscience

Anatomo-functional changes in neural substrates of cognitive memory in developmental amnesia: Insights from automated and manual MRI examinations

Loïc J. Chareyron, Wui Khean Chong, Tina Banks, Neil Burgess, Richard C. Saunders, Faraneh Vargha‐Khadem

The paper examines structural brain changes in developmental amnesia patients using MRI and finds that hippocampal atrophy correlates with cognitive performance, suggesting cortical compensation for damaged regions.

bioRxiv · Jan 23, 2023 · PreprintNeuroscience

Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development

Teresa G. Krieger, Carla Moran, Alberto Frangini, W. Edward Visser, Erik Schoenmakers, Francesco Muntoni A, Chris A. Clark, David G. Gadian, Wui Khean Chong, Adam Kuczynski, Mehul Dattani, Greta Lyons, Alexandra Efthymiadou, Faraneh Vargha‐Khadem, Benjamin D. Simons, , Frederick J. Livesey

This study shows that THRA mutations impair neural progenitor cell proliferation and organisation in human cortical development using patient-derived iPSCs.

Proceedings of the National Academy of Sciences · Oct 18, 2019Peer-reviewedDevelopmental Biology