W. Edward Visser

Molecular mechanism of thyroxine transport by monocarboxylate transporters

This study determines the structures of MCT8 and MCT10 in different states to elucidate the molecular mechanism of thyroid hormone transport and explain disease-related mutations.

Triac treatment prevents neurodevelopmental and locomotor impairments in thyroid hormone transporter Mct8/Oatp1c1 deficient mice

This study compares Triac and Ditpa in Mct8/Oatp1c1 deficient mice, finding Triac more effective in improving CNS development and locomotor function when administered early postnatally.

Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development

This study shows that THRA mutations impair neural progenitor cell proliferation and organisation in human cortical development using patient-derived iPSCs.