Frederick J. Livesey

This study shows that ECM defects in Down syndrome neurodevelopment cause apical cytoarchitecture and mechanical property instability in neural stem cell models.

This study shows that kinesin-1 and kinesin-3 mitigate Aβ42Arc toxicity in Drosophila neurons and rescue behavioral defects.

This study shows that extracellular tau's synaptotoxic effects are mediated by its microtubule-binding region, and targeting this region can reverse synaptic plasticity disruption.

This study shows human astrocytes generate and release amyloid-β aggregates under lysosomal stress, contributing to extracellular Aβ accumulation in Alzheimer's disease.

The paper shows that inhibiting NAT10 corrects nuclear defects and extends lifespan in tauopathy models.

BigNeuron benchmarks automatic neuron reconstruction algorithms using gold standard annotations and image quality metrics, showing that consensus methods outperform individual algorithms.

The paper identifies LRRK2-regulated pathways for extracellular tau uptake in human neurons using CRISPR screens, showing LRRK2's role in monomeric tau endocytosis.

The paper constructs a single-cell atlas of the frontal cortex in early-onset monogenic Alzheimer's disease to identify cellular and molecular changes in disease mechanisms.

This study shows that THRA mutations impair neural progenitor cell proliferation and organisation in human cortical development using patient-derived iPSCs.

This study shows that tau mutations in FTD cause hyperphosphorylation, mislocalization, and nuclear membrane deformation, leading to defective nucleocytoplasmic transport.

The paper investigates how monomeric and aggregated tau enter human neurons through distinct pathways, identifying dynamin- and actin-dependent mechanisms for monomeric tau and dynamin-dependent clathrin-mediated endocytosis for aggregated tau.