Drug repurposing: halogenated salicylanilides inhibit USP8 catalytic activity and ACTH release by pituitary cells
Thierry Waltrich-Augusto, Magda Mortier, Caroline Barette, Emmanuelle Soleilhac, Laurence Aubry, Marie‐Odile Fauvarque
This study identifies halogenated salicylanilides, including Closantel, as USP8 inhibitors that reduce ACTH secretion in pituitary cells, suggesting therapeutic potential for Cushing's disease and cancer.
bioRxiv · Feb 26, 2025 · PreprintPharmacology & Toxicology