Caroline Barette

This paper shows that the SF3B1 inhibitor pladienolide B inhibits DNA damage repair and counteracts platinum resistance in NSCLC by inducing genomic instability and altering DNA repair gene splicing.

This study identifies halogenated salicylanilides, including Closantel, as USP8 inhibitors that reduce ACTH secretion in pituitary cells, suggesting therapeutic potential for Cushing's disease and cancer.