Dysfunctional LHX6 pallido-subthalamic projections mediate epileptic events in a mouse model of Leigh Syndrome
Laura Sánchez-Benito, Melania González-Torres, Irene Fernández-González, Laura Cutando, María Royo, Joan Compte, Miquel Vila, Sandra Jurado, Elisenda Sanz, Albert Quintana
This study identifies dysfunctional pallido-subthalamic projections as a mediator of epilepsy in a mouse model of Leigh Syndrome and suggests STN inhibition as a potential therapeutic target.
Journal of Clinical Investigation · Oct 2, 2025Peer-reviewedNeuroscience