Joan Compte

This study identifies dysfunctional pallido-subthalamic projections as a mediator of epilepsy in a mouse model of Leigh Syndrome and suggests STN inhibition as a potential therapeutic target.

LRRK2 G2019S iPSC-derived microglia exposed to neuromelanin, but not α-synuclein fibrils, reduce healthy dopaminergic neuron numbers in co-culture; ivermectin prevents this, and post-mortem midbrain supports it.

This paper standardises and automates the quantification of intracellular neuromelanin granules in human brain tissue sections using TruAI, revealing age-related changes in their properties.

This paper creates a transgenic mouse model that mimics human neuromelanin accumulation in catecholaminergic neurons, leading to age-related neurodegenerative deficits.

Transcranial focused ultrasound reduces neuromelanin accumulation and provides therapeutic benefits in parkinsonian rats without additional interventions.

This study reduces age-related neuromelanin accumulation in a humanized rodent model, mitigating Parkinson's disease features by preserving dopamine homeostasis and neuronal integrity.