Nicholas P. Illsley

Epigenetic changes regulating the epithelial-mesenchymal transition in human trophoblast differentiation

The paper identifies an epithelial-mesenchymal transition (EMT) mechanism in human trophoblast differentiation, linking DNA methylation changes to gene expression and invasion capacity.

Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs

The paper maps allele-specific DNA methylation in normal and cancer tissues, identifying disease-associated regulatory SNPs that are missed by other methods.

DNA Methylation Explains a Subset of Placental Gene Expression Differences Based on Ancestry and Altitude

The paper examines how DNA methylation influences gene expression differences in placental tissue between Andean and European ancestry individuals at high and low altitudes, finding more methylation regulation in ancestry-related genes.