Benjamin Tycko

The paper maps R-loop landscapes in the developing human brain and shows their role in neural differentiation and gene expression programs.

This study shows PFOS exposure disrupts membrane signaling and epithelial integrity in fallopian tube cells by altering stress-response pathways and lipid homeostasis.

The paper identifies an epithelial-mesenchymal transition (EMT) mechanism in human trophoblast differentiation, linking DNA methylation changes to gene expression and invasion capacity.

The paper identifies an epistatic interaction between genetic ethnicity and hypertension that explains racial disparities in multiple myeloma risk among Black and mixed-ancestry individuals.

The paper maps allele-specific DNA methylation in normal and cancer tissues, identifying disease-associated regulatory SNPs that are missed by other methods.

CloudASM provides an efficient cloud-based pipeline for quantifying allele-specific DNA methylation by leveraging Google Cloud Computing infrastructure.