Douglas J. Cook

Repeated Subconcussive Head Impacts Compromise White Matter Integrity and Bimanual Coordination in Collegiate Football Players

This study finds that repeated subconcussive head impacts in collegiate football players are linked to white matter microstructure changes and motor coordination deficits, not detected by standard symptom assessments.

Brain Charts for the Rhesus Macaque Lifespan

This study creates normative brain growth charts for rhesus macaques across their lifespan using MRI data, revealing developmental milestones and cross-species comparisons with humans.

Spontaneous behavioural recovery following stroke relates to the integrity of sensory and association cortices

This study shows that preservation of sensory and association cortices predicts spontaneous behavioural recovery after stroke in macaques.

Convergence of proprioceptive and visual feedback on neurons in primary motor cortex

The paper examines how visual and proprioceptive feedback influences activity in primary motor cortex neurons, finding that ~73% of neurons respond to at least one feedback source and that limb and goal feedback converge on the same neurons.

Comparison of cerebrospinal fluid biomarkers relevant to neurodegenerative diseases in healthy cynomolgus and rhesus macaque monkeys

The paper compares cerebrospinal fluid biomarkers in cynomolgus and rhesus macaques, finding species and sex differences in concentrations of amyloid-beta, tau, and neurofilament light.

Muting, not fragmentation, of functional brain networks under general anesthesia

This paper shows that apparent fragmentation of brain networks under anesthesia is due to reduced functional connectivity, not structural changes.

Maintained representations of the ipsilateral and contralateral limbs during bimanual control in primary motor cortex.

This study shows that primary motor cortex maintains representations of both ipsilateral and contralateral limbs during bimanual movements, with greater stability in contralateral limb representations.

Causal roles of frontoparietal cortical areas in feedback control of the limb

This study shows that cooling dorsal premotor cortex and parietal area 5 in monkeys impairs motor corrections, with distinct effects on speed and accuracy, supporting their roles in feedback control.

Keep your hands apart: independent representations of ipsilateral and contralateral forelimbs in primary motor cortex

The paper shows that primary motor cortex neurons respond independently to contralateral and ipsilateral arm movements, with distinct response magnitudes and timing, and that these responses are segregated into orthogonal subspaces.