Tomohiko Takei

Autogenic spinal excitatory circuit ensures skilled hand movements in primates

This study identifies spinal excitatory circuits critical for skilled hand movements in primates, showing pre-determined muscle activation patterns during motor planning.

Spinal and cortical premotor control of primate dexterous hand movements

This study investigates the functional differences between direct corticomotoneuronal and indirect corticospinal pathways in primate hand movement control during a precision grip task.

Global disinhibition and corticospinal plasticity for drastic recovery after spinal cord injury

This study shows that global disinhibition and corticospinal plasticity enable drastic motor recovery after spinal cord injury in macaques through intensive training and cortical electrical stimulation.

Neural network models for spinal implementation of muscle synergies

The paper compares neural network models to determine a biologically plausible explanation for how muscle synergies are implemented in the spinal cord, finding that a population model with moderate variation matches experimental data.

Causal roles of frontoparietal cortical areas in feedback control of the limb

This study shows that cooling dorsal premotor cortex and parietal area 5 in monkeys impairs motor corrections, with distinct effects on speed and accuracy, supporting their roles in feedback control.

Distinct sensorimotor feedback loops for dynamic and static control of primate precision grip

The paper investigates distinct neural circuits for dynamic and static control of primate precision grip through coherence analysis between spinal cord, motor cortex, and EMG signals.

Keep your hands apart: independent representations of ipsilateral and contralateral forelimbs in primary motor cortex

The paper shows that primary motor cortex neurons respond independently to contralateral and ipsilateral arm movements, with distinct response magnitudes and timing, and that these responses are segregated into orthogonal subspaces.

Two distinct proprioceptive representations of voluntary movements in primate spinal neurons

The paper records spinal neuron activity in monkeys during voluntary wrist movements and finds two distinct groups with different firing patterns and input-output control, suggesting coordinated proprioceptive representation.