Cytotoxic activity against human leukemia cells of Kaempferol-3-O-rhamnoside from Vietnamese Schima wallichii (DC.) Korth: A combination of in vitro and in silico insights
Manh Hung Tran, Yến Nhi Nguyễn, Thuy Mi Pham Lam, Thuy Linh Thi Tran, Tấn Khanh Nguyễn, Anh Tuấn Lê, Van Ngo Thai Bich, Hieu Phu Chi Truong, Phu Tran Vinh Pham
This study identifies kaempferol-3-O-rhamnoside from Schima wallichii as a cytotoxic compound against leukemia cells, showing in vitro and in silico evidence of its mechanism involving caspase activation and PARP1 inhibition.
bioRxiv · Dec 25, 2024 · PreprintPharmacology & Toxicology