Multi-omic approach to identify phenotypic modifiers underlying cerebral demyelination in X-linked adrenoleukodystrophy
Phillip A. Richmond, Frans M. van der Kloet, Frédéric Maxime Vaz, David T S Lin, Anuli Christiana Uzozie, Emma Graham, Michael Steffen Kobor, Sara Mostafavi, Perry D. Moerland, Philipp F. Lange, Antoine H. C. van Kampen, Wyeth W. Wasserman, Marc Engelen, Stephan Kemp, Clara van Karnebeek
This study uses multi-omic profiling of blood samples from ALD patients to identify molecular markers predictive of cerebral demyelination, but finds no statistically significant markers due to high inter-individual variation.
Frontiers in Cell and Developmental Biology · Jun 25, 2020Peer-reviewedGenetic & Genomic Medicine