Perry D. Moerland

The paper uses a 3D CLL spheroid model to study how lymph node microenvironmental signals influence CLL cell phenotypes and drug responses to ibrutinib.

This study evaluates how deconvolution methods for spatial transcriptomics data perform when cell types are missing from reference datasets, finding that performance decreases with the number of missing cell types.

The paper identifies CD32+ CD4+ T cells as a rare, cytotoxic memory subset enriched for HIV-1 DNA in treated patients.

This paper identifies specific macrophage subsets in ANCA-associated glomerulonephritis that drive inflammation and fibrosis, suggesting therapeutic targets.

The paper examines microglia nodules in multiple sclerosis and finds they are associated with higher lesion load and specific gene expression changes compared to stroke.

This study shows that Per1 and Per2 are required for the daily rhythm of photoreceptor outer segment phagocytosis, with the RPE driving this process transcriptionally.

This study quantifies transcription bursting genome-wide in breast cancer cells using 4sUDRB-sequencing and finds burst sizes up to 160 transcripts, with correlations to promoter features and drug response.

The paper identifies DNA methylation markers associated with endocrine therapy resistance in ER+/HER2- breast cancer using TCGA data and cell line experiments.

This study uses multi-omic profiling of blood samples from ALD patients to identify molecular markers predictive of cerebral demyelination, but finds no statistically significant markers due to high inter-individual variation.