Metabolic flux partitioning between the TCA cycle and glyoxylate shunt combined with a reversible methyl citrate cycle provide nutritional flexibility for Mycobacterium tuberculosis
Khushboo Borah, Tom A. Mendum, Nathaniel D. Hawkins, Jane L. Ward, Michael H. Beale, Gerald J Larrouy-Maumus, Apoorva Bhatt, Martine Moulin, Michael Haertlein, Gernot A. Strohmeier, Harald Pichler, V. Trevor Forsyth, Stephen Noack, Celia W. Goulding, Johnjoe McFadden, Dany J. V. Beste
This paper identifies the metabolic flux partitioning between the TCA cycle, glyoxylate shunt, and reversible methyl citrate cycle in Mtb as critical for its nutritional flexibility when co-metabolizing carbon substrates.
bioRxiv · Jan 29, 2021 · PreprintSystems Biology