Tom A. Mendum

VadK, a Non-Canonical Kinase that Regulates the Methylcitrate Cycle and is Essential for Mycobacterium tuberculosis Virulence

Phosphoserine aminotransferase SerC is a central metabolic checkpoint and druggable vulnerability in Mycobacterium tuberculosis

This study identifies SerC as a critical metabolic enzyme in Mtb, showing its essential role in survival and revealing it as a potential drug target for TB therapy.

Mosquito NF-κB-mediated innate immunity exerts arbovirus-specific antiviral effects at multiple stages of the viral life cycle

This study shows that mosquito NF-κB-mediated immunity broadly suppresses arbovirus replication but has virus-specific effects, highlighting the complexity of antiviral barriers in mosquitoes.

Metabolic flux partitioning between the TCA cycle and glyoxylate shunt combined with a reversible methyl citrate cycle provide nutritional flexibility for Mycobacterium tuberculosis

This paper identifies the metabolic flux partitioning between the TCA cycle, glyoxylate shunt, and reversible methyl citrate cycle in Mtb as critical for its nutritional flexibility when co-metabolizing carbon substrates.

A systematic evaluation of Mycobacterium tuberculosis Genome-Scale Metabolic Networks

This study evaluates eight Mtb metabolic models to identify the best performing ones and refine them for future research.