Author
University of BirminghamORCID 0000-0002-6655-1636Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Gregory H. Babunovic, Sanne van der Niet, Marco Túlio Pardini Gontijo…·David Branch Moody
The paper identifies pks12 as an in vivo essential gene in Mtb by combining genomic, metabolomic, and phenotypic analyses, revealing its role in mycolyl lipid synthesis and host-pathogen interface structure.
Selva Rupa Christinal Immanuel, Julie Do, Eliza J. R. Peterson…·Nitin S. Baliga
The paper shows adenylyl cyclase agonists inhibit Mtb growth by rerouting carbon to virulence lipids through ETC blockade and cAMP-driven metabolic remodeling.
Jordan Pascoe, Jane Newcombe, Jessica Mendoza…·Dany J. V. Beste
Eliza J. R. Peterson, Aaron N. Brooks, David J. Reiss…·Nitin S. Baliga
This study identifies MtrA as a critical regulator of peptidoglycan cleavage in Mtb, essential for survival under acidic stress and a potential drug target.
Khushboo Borah, Tom A. Mendum, Nathaniel D. Hawkins…·Dany J. V. Beste
This paper identifies the metabolic flux partitioning between the TCA cycle, glyoxylate shunt, and reversible methyl citrate cycle in Mtb as critical for its nutritional flexibility when co-metabolizing carbon substrates.
Vipul Navinchandra Panchal, Nidhi Jatana, Anchal Malik…·Vivek Rao
The paper identifies a mutation in the papA2 gene of Mycobacterium tuberculosis that leads to loss of sulfolipids by disrupting protein stability and structure.