Target-based de novo design of cyclic peptide binders
Fanhao Wang, Tiantian Zhang, Jintao Zhu, Xiaoling Zhang, Changsheng Zhang, Luhua Lai
This paper introduces CYC_BUILDER, a reinforcement learning method for designing cyclic peptides that bind target proteins, demonstrating its effectiveness in generating potent inhibitors for TNF.
bioRxiv · Jan 18, 2025 · PreprintBiochemistry