Changsheng Zhang

This paper introduces CYC_BUILDER, a reinforcement learning method for designing cyclic peptides that bind target proteins, demonstrating its effectiveness in generating potent inhibitors for TNF.

The paper determines the crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain and identifies unique features for antiviral drug targeting.

This paper reports the cryo-EM structure of Mycobacterium tuberculosis RNAP holoenzyme bound to fidaxomicin, revealing its unique binding site and mechanism of transcription inhibition.