Author

Thomas A. Agbaedeng

Centre for Human GeneticsORCID 0000-0002-4399-9139Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:ATAC-seq· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Christopher A. O’CallaghaniD· 3 shared Jiahao JiangiD· 3 shared Thomas K. HironiD· 3 shared Yashaswat MalhotraiD· 3 shared Anil ChaliseyiD· 1 shared Edward DrydaleiD· 1 shared Esther NgiD· 1 shared Goutham AtlaiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersGenomics

Christopher A. O’CallaghanORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintApr 23, 2026

CAD variants act through ox-LDL-induced enhancer remodelling to alter VSMC gene programmes

Thomas A. Agbaedeng, Goutham Atla, Thomas K. Hiron…·Christopher A. O’Callaghan

The paper identifies CAD risk variants that alter VSMC gene programs via ox-LDL-induced enhancer remodelling using multi-omics approaches.

DOI 10.64898/2026.04.21.718843

humanbulk RNA-seq

𝕏 PostBluesky

GenomicsScientific ReportsPeer-reviewedJul 1, 2025

Ox-LDL induces a non-inflammatory response enriched for coronary artery disease risk in human endothelial cells

Jiahao Jiang, Thomas K. Hiron, Anil Chalisey…·Christopher A. O’Callaghan

This study identifies ox-LDL-induced non-inflammatory changes in endothelial cells that are enriched for coronary artery disease risk.

11 citations

humanbulk RNA-seq

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GeneticsbioRxivPreprintSep 14, 2023

Partitioning heritability using single-cell multi-omics identifies a novel macrophage subpopulation conveying genetic risks of coronary artery disease.

Jiahao Jiang, Thomas K. Hiron, Thomas A. Agbaedeng…·Christopher A. O’Callaghan

The paper identifies a novel macrophage subpopulation, lipid-handling macrophages, that is enriched with CAD genetic risk and shows how a risk variant affects FDX1 through AP-1 and C/EBP-beta recruitment.

1 citation

𝕏 PostBluesky