This study identifies clonal persistence, tertiary lymphoid structures (TLS) engagement, and coordinated B-T cell immune surveillance as hallmarks of durable tumour control in a long-term survivor of metastatic ccRCC.

bioRxiv · Dec 22, 2025 · PreprintCancer Biology

Remodelled cholesteryl ester enriched lipid droplets fuel flavivirus morphogenesis

Adrianna Banducci-Karp, Sophie Brixton, Pranav N. M. Shah, Mingyuan Li, Georgina Fisher, Joey Riepsaame, Raman Dhaliwal, Katie L. Holden, Edward Drydale, James Bancroft, Charlotte E. Melia, Gathsaurie Neelika Malavige, Sumana Sanyal

This study identifies cholesteryl ester-enriched lipid droplets as critical host components required for flavivirus infection and shows their role in viral morphogenesis.

bioRxiv · Jun 7, 2025 · PreprintCell Biology

Horizontal transfer of nuclear DNA in transmissible cancer

Kevin C. Gori, Adrian Baez‐Ortega, Andrea Strakova, Maximilian R. Stammnitz, Jinhong Wang, Jonathan Chan, Katherine Hughes, Sophia Belkhir, Maurine Hammel, Daniela Moralli, James M. Bancroft, Edward Drydale, Karen M. Allum, María Verónica Brignone, Anne M. Corrigan, , Elizabeth P. Murchison

The paper detects a single instance of host-to-tumour horizontal DNA transfer in canine transmissible venereal tumour, showing a 15-megabase genetic element from a dog with Middle Eastern ancestry.

Proceedings of the National Academy of Sciences · Apr 22, 2025Peer-reviewedCancer Biology

Partitioning heritability using single-cell multi-omics identifies a novel macrophage subpopulation conveying genetic risks of coronary artery disease.

Jiahao Jiang, Thomas K. Hiron, Thomas A. Agbaedeng, Yashaswat Malhotra, Edward Drydale, James M. Bancroft, Esther Ng, Michael E. Reschen, Lucy J. Davison, Christopher A. O’Callaghan

The paper identifies a novel macrophage subpopulation, lipid-handling macrophages, that is enriched with CAD genetic risk and shows how a risk variant affects FDX1 through AP-1 and C/EBP-beta recruitment.

bioRxiv · Sep 14, 2023 · PreprintGenetics