Author

Thomas K. Hiron

Centre for Human GeneticsORCID 0000-0001-9062-8472Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Immunology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Christopher A. O’CallaghaniD· 5 shared Jiahao JiangiD· 4 shared Thomas A. AgbaedengiD· 3 shared Yashaswat MalhotraiD· 3 shared Lucy J. DavisoniD· 2 shared Adam J. MeadiD· 1 shared Anil ChaliseyiD· 1 shared Anja KipariD· 1 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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5 shared papersGenomics

Christopher A. O’CallaghanORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CAD variants act through ox-LDL-induced enhancer remodelling to alter VSMC gene programmes

Thomas A. Agbaedeng, Goutham Atla, Thomas K. Hiron, Jiahao Jiang, Yashaswat Malhotra, Lewis Marsh, Joanna M. M. Howson, Christopher A. O’Callaghan

The paper identifies CAD risk variants that alter VSMC gene programs via ox-LDL-induced enhancer remodelling using multi-omics approaches.

bioRxiv · Apr 23, 2026 · PreprintGenomics

Fatal consequences of feline coronavirus infection are associated with virus persistence and a distinct adaptive immune repertoire

Thomas K. Hiron, Sara Falcone, Anja Kipar, Melanie Hezzell, Christopher A. O’Callaghan, Emi Barker, Lucy J. Davison

This study identifies immune repertoire changes and viral evolution in feline coronavirus infection, linking them to FIP severity and outcomes.

bioRxiv · Oct 2, 2025 · PreprintImmunology

Hypercholesterolaemia promotes epigenetic memory in hematopoietic stem cells that persists after lipid lowering and causes systemic immunometabolic dysfunction mediated by macrophage metabolic reprogramming

Gareth S. D. Purvis, Jiahao Jiang, Thomas K. Hiron, Christina Simoglou Karali, Matthew D. Baxter, Rong Li, Rohit Vijjhalwar, Marina Diotallevi, Sally A. V. Draycott, Surawee Chuaiphichai, Gillian Douglas, Eileen McNeill, Adam J. Mead, David R. Greaves, Christopher A. O’Callaghan, Keith M. Channon

This study shows that high cholesterol induces epigenetic changes in hematopoietic stem cells that persist after cholesterol reduction, leading to systemic immunometabolic dysfunction.

bioRxiv · Sep 15, 2025 · PreprintImmunology

Ox-LDL induces a non-inflammatory response enriched for coronary artery disease risk in human endothelial cells

Jiahao Jiang, Thomas K. Hiron, Anil Chalisey, Yashaswat Malhotra, Thomas A. Agbaedeng, Christopher A. O’Callaghan

This study identifies ox-LDL-induced non-inflammatory changes in endothelial cells that are enriched for coronary artery disease risk.

Scientific Reports · Jul 1, 2025Peer-reviewedGenomics

Partitioning heritability using single-cell multi-omics identifies a novel macrophage subpopulation conveying genetic risks of coronary artery disease.

Jiahao Jiang, Thomas K. Hiron, Thomas A. Agbaedeng, Yashaswat Malhotra, Edward Drydale, James M. Bancroft, Esther Ng, Michael E. Reschen, Lucy J. Davison, Christopher A. O’Callaghan

The paper identifies a novel macrophage subpopulation, lipid-handling macrophages, that is enriched with CAD genetic risk and shows how a risk variant affects FDX1 through AP-1 and C/EBP-beta recruitment.

bioRxiv · Sep 14, 2023 · PreprintGenetics