Author

David M. Cheek

Harvard UniversityORCID 0000-0002-4429-7315Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Kamila NaxerovaiD· 2 shared Martin BlohmeriD· 2 shared Alexander N. GorelickiD· 1 shared Dejan JuriciD· 1 shared Djamila BoermaiD· 1 shared Emma C. E. WassenaariD· 1 shared Emma V. WatsoniD· 1 shared Emre KüçükköseiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Kamila NaxerovaORCID

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2 papers

Recent·Most cited

Age distinguishes selection from causation in cancer genomes

David M. Cheek, Martin Blohmer, Martin A. Nowak, Tibor Antal A, Kamila Naxerova

The paper distinguishes between mutations that drive cancer and those that arise from normal tissue evolution by analyzing patient age across cancer and normal genomes.

Nature Genetics · May 5, 2026Peer-reviewedCancer Biology

A unique interplay of access and selection shapes peritoneal metastasis evolution in colorectal cancer

Emma C. E. Wassenaar, Alexander N. Gorelick, Wei-Ting Hung, David M. Cheek, Emre Küçükköse, I‐Hsiu Lee, Martin Blohmer, Sebastian Degner, Peter Giunta, Marinus J. Wiezer, Mihaela G. Raicu, Inge Ubink, Sjoerd J. Klaasen, Nico R. Lansu, Emma V. Watson, , Kamila Naxerova

This study examines the evolutionary dynamics of peritoneal metastases in colorectal cancer, finding they are more heterogeneous than liver metastases but less diverse than locoregional metastases.

bioRxiv · Sep 25, 2024 · PreprintGenetics