Martin A. Nowak

The paper exhaustively analyzes binary memory-two strategies in symmetric two-player games to determine cooperation rates and Nash equilibria across all possible games.

This study examines ecDNA in lung cancer, finding it in 18.9% of patients and associating it with worse survival and genomic instability.

The paper distinguishes between mutations that drive cancer and those that arise from normal tissue evolution by analyzing patient age across cancer and normal genomes.

This study identifies three distinct evolutionary trajectories in lung adenocarcinomas using whole-genome sequencing, revealing that some never-smoking tumors follow smoking-like paths driven by KRAS mutations.

This study analyzes 1024 lung adenocarcinomas to identify evolutionary patterns and mutational mechanisms, revealing distinct trajectories linked to smoking, ancestry, and retrotransposition.

The paper calculates the variance of genetic relatedness for general pedigrees, showing it depends on recombination process features like crossover interference and chromosome size.

The paper introduces a new measure of genome-wide genetic shuffling that accounts for crossover positions and Mendel’s second law, showing it is nearly maximal in humans due to independent assortment.

This study shows that CRISPR gene drives can invade wild populations even with resistance alleles, challenging claims that they are safe for release.