Author

Alham Saadat

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Research Focus:variant effect prediction· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Melina ClaussnitzeriD· 4 shared Adam Štefek· 2 shared Elizabeth R. McGonagleiD· 2 shared Hesam DashtiiD· 2 shared Nasa Sinnott-ArmstrongiD· 2 shared Saaket AgrawaliD· 2 shared Samantha LaberiD· 2 shared Sophie StrobeliD· 2 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersGenomics

Melina ClaussnitzerORCID

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4 papers

Recent·Most cited

The 9p21.3 Coronary Artery Disease Risk Locus Modulates Vascular Cell-State Transitions via Enhancer-Driven Regulation of MTAP

Timothy N. Audam, Benjamin Schmandt, Yi Huang, Young Beum Cho, Mayank Murali, Rama Kaalia, Saaket Agrawal, Jinping Liu, Hongjie Shi, Zhou Yuan, Dengwei Cao, Lan Jiang, Yun Li, Jichen Wen, Zhao Hongqiang, , Melina Claussnitzer

This study identifies 12 enhancers in the 9p21.3 CAD risk locus that regulate MTAP, modulating vascular cell-state transitions and CAD risk through stress-responsive mechanisms.

bioRxiv · Nov 18, 2025 · PreprintGenomics

Discovering cellular programs of intrinsic and extrinsic drivers of metabolic traits using LipocyteProfiler

Samantha Laber, Sophie Strobel, Josep Maria Mercader, Hesam Dashti, Felipe R. C. dos Santos, Phil Kubitz, Maya Jackson, Alina Ainbinder, Julius Honecker, Saaket Agrawal, Garrett Garborcauskas, David R. Stirling, Aaron Leong, Katherine Figueroa, Nasa Sinnott-Armstrong, , Melina Claussnitzer

The paper introduces LipocyteProfiler, a high-throughput microscopy assay to profile lipid-storing cells and identifies cellular programs linked to metabolic traits like insulin resistance and lipodystrophy.

Cell Genomics · Jun 20, 2023Peer-reviewedGenomics

Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function

Mi Ni Huang, Daniel Coral, Hamidreza Ardalani, Peter Spégel, Alham Saadat, Melina Claussnitzer, Hindrik Mulder, Paul W. Franks, Sebastian Kalamajski

The paper identifies a causal eQTL at MTIF3 associated with weight loss and shows MTIF3 deficiency affects adipocyte mitochondrial function and lipid metabolism.

eLife · Mar 6, 2023Peer-reviewedGenetics

High-resolution genome-wide functional dissection of transcriptional regulatory regions in human

Xinchen Wang, Liang He, Sarah M. Goggin, Alham Saadat, Li Wang, Nasa Sinnott-Armstrong, Melina Claussnitzer, M Kellis

The paper introduces HiDRA, a method for high-resolution functional analysis of regulatory regions, identifying 13,000 driver elements and linking them to disease-associated variants.

Nature Communications · Dec 13, 2018Peer-reviewedGenomics