GenomicsProceedings of the National Academy of SciencesPeer-reviewed
Direct Quantification of in vivo Mutagenesis and Carcinogenesis Using Duplex Sequencing
Charles C. Valentine, Robert R. Young, Mark R. Fielden…·Jesse J. Salk
This paper demonstrates that Duplex Sequencing, an error-corrected NGS method, can accurately quantify in vivo mutagenesis and early signs of carcinogenesis in mice, outperforming traditional transgenic rodent assays.
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