Dual role of the OMM E3 Ub ligase MARCH5 in de novo peroxisome biogenesis and mitochondrial quality control through direct regulation of Pex26.
Debduti Bhattacharjee, Claudia Christiane Bippes, Guiling Zhao, Liron Boyman, Mehari M Weldemariam, Maureen A. Kane, Albert Neutzner, Mariusz Karbowski
This study identifies MARCH5 as a dual regulator of peroxisome biogenesis and mitochondrial quality control by ubiquitinating Pex26.
bioRxiv · May 11, 2026 · PreprintCell Biology