Maureen A. Kane

Regulation of protein kinase pathways in primary neuron model of anti-NMDA receptor encephalitis.

This study investigates how a GluN1 monoclonal antibody affects kinase signaling pathways in primary cortical neurons, revealing phosphoproteomic changes linked to NMDAR activation.

Rubicon modulates neuroimmune responses following traumatic brain injury

This study shows that Rubicon promotes neuroinflammation and oxidative stress after traumatic brain injury by affecting autophagy and ROS production, and suggests it as a potential therapeutic target.

Dual role of the OMM E3 Ub ligase MARCH5 in de novo peroxisome biogenesis and mitochondrial quality control through direct regulation of Pex26.

This study identifies MARCH5 as a dual regulator of peroxisome biogenesis and mitochondrial quality control by ubiquitinating Pex26.

Intranasal Delivery of HIV/SIV Antigens with NE/AS01B Adjuvants Enhances Cellular Immunity and Reduces Viral Loads in SHIV-Challenged Macaques

Achilles tendons of MRL/MpJ mice show scar-mediated healing after tenotomy

This study compares tendon healing in MRL/MpJ and C57BL/6J mice after Achilles tenotomy, finding scar formation in MRL/MpJ mice and differences in ossification and signaling pathways.

Lysosomal multi-omics reveals altered sphingolipid catabolism as driver of lysosomal dysfunction in the aging brain.

The paper uses multi-omics analysis of lysosomes to identify age-related sphingolipid catabolism changes linked to lysosomal dysfunction in the aging brain.

Inhibition of autophagy-lysosomal function exacerbates microglial and monocyte lipid metabolism reprograming and dysfunction after brain injury

This study shows that inhibiting autophagy-lysosomal function worsens lipid metabolism reprogramming and dysfunction in microglia and monocytes after brain injury.

All-trans retinoic acid and fluid transport in myopigenesis

The paper measures all-trans retinoic acid (atRA) concentrations in mice and develops a model to understand its transport and role in myopia development.

Lipid Nanoparticles from L. meyenii Walp Mitigate Sepsis through Multimodal Protein Corona Formation

This study identifies lipid nanoparticles from maca that reduce inflammation and improve survival in sepsis models by sequestering pro-inflammatory cytokines and acute phase proteins.

Modulation of all-trans retinoic acid by light and dopamine in the murine eye

This study investigates how ambient light and dopamine affect all-trans retinoic acid levels in the mouse eye, finding that light exposure reduces atRA and that dopamine influences atRA levels.

Studies of all-trans retinoic acid transport in myopigenesis

This study evaluates a fluorescent analog of all-trans retinoic acid as a surrogate for studying its transport and distribution in ocular tissues.

Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves

This study uses spatial transcriptomics to analyze human embryonic arterial valves, identifying novel genes and pathways involved in valve development and highlighting limitations in current genomic databases.

Elevated serotonin in mouse spinal dorsal horn is pronociceptive

The paper investigates the role of serotonin in pain modulation, finding that sustained serotonin signaling in the spinal trigeminal nucleus is pronociceptive in chronic pain models.

MRP5 and MRP9 Play a Concerted Role in Male Reproduction and Mitochondrial Function

This study shows that MRP5 and MRP9 work together in male reproduction and mitochondrial function through their localization to mitochondrial-associated membranes and their roles in heme transport and metabolic regulation.