Author

Mahesh S. Iyer

Indian Institute of Technology BombayORCID 0000-0002-4495-9462Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 3

Signature Assays, Organisms & Methods

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Organism:E. coli· 3 Research Focus:differential expression· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Ankita PaliD· 3 shared Kareenhalli Viswanath VenkateshiD· 3 shared Sumana SrinivasaniD· 2 shared Aswin Sai Narain SeshasayeeiD· 1 shared Pramod Rajaram SomvanshiiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 9 mutual co-author links

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3 shared papersSystems Biology

Ankita PalORCID

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3 papers

Recent·Most cited

Systems BiologyMicrobiology SpectrumPeer-reviewedFeb 7, 2023

A systems biology approach to disentangle the direct and indirect effects of global transcription factors on gene expression in Escherichia coli

Mahesh S. Iyer, Ankita Pal, Kareenhalli Viswanath Venkatesh

The paper quantifies direct and indirect effects of global TFs on gene expression in E. coli using deletion mutants and computational analysis.

6 citations

E. colibulk RNA-seq

Systems BiologyOpen BiologyPeer-reviewedFeb 1, 2022

Global pleiotropic effects in adaptively evolved Escherichia coli lacking CRP reveal molecular mechanisms that define growth physiology

Ankita Pal, Mahesh S. Iyer, Sumana Srinivasan…·Kareenhalli Viswanath Venkatesh

This study shows how deleting CRP in E. coli leads to metabolic and proteomic changes that allow growth recovery through mutations and pathway re-allocation.

19 citations

E. colimetabolomics

Systems BiologybioRxivPreprintJul 17, 2020

Global transcriptional regulators fine-tune the translational and metabolic machinery in Escherichia coli under anaerobic fermentation

Mahesh S. Iyer, Ankita Pal, Sumana Srinivasan…·Kareenhalli Viswanath Venkatesh

The paper investigates the role of global transcriptional regulators in Escherichia coli under anaerobic fermentation, showing their impact on metabolic and translational efficiency and growth rates.

2 citations

E. colimetabolomics