Aswin Sai Narain Seshasayee

The paper uses phylogenetic analysis to show that bacterial σ-factors evolved from single-domain DNA-binding transcription factors through domain fusion.

The paper traces the evolutionary history of transcription factor repertoires in prokaryotes, finding early diversification and steady innovation contrasting with eukaryotic bursts.

This study analyzes the evolutionary distribution of trehalose breakdown pathways across 4000 genomes, revealing ancestral origins and lineage-specific losses.

The paper analyzes the evolutionary divergence of DNA binding and transcriptional activation functions in the CRP/FNR family across prokaryotic genomes.

This paper investigates how DNA binding proteins evolved sequence specificity by analyzing the IHF/HU family and reconstructing ancestral sequences.

This study shows that altering macrophage metabolism can reduce drug tolerance in Mycobacterium tuberculosis by affecting bacterial redox states.

The paper examines the evolutionary dynamics of transcription factor and non-transcription factor DNA-binding superfamilies across eukaryotic clades, revealing differences in their scaling and evolutionary rates.

The paper identifies long DNA repeats in bacterial genomes and shows their positioning is non-random and constrained by replication-dependent organisation in fast and slow-growing bacteria.

The paper uses phenomenological models to analyze how E. coli genes respond to varying cAMP concentrations, revealing gene-specific parameters and functional class tuning.

This study shows how deleting CRP in E. coli leads to metabolic and proteomic changes that allow growth recovery through mutations and pathway re-allocation.

The paper shows Gcn4/ATF4 regulates metabolic precursor biosynthesis and translation capacity in yeast growth programs, balancing metabolic supply with translation output.

This study investigates the evolutionary distribution of bacterial non-homologous end joining (NHEJ) through comparative genomics and phylogenetic analysis across 6000 genomes, finding it is sporadic and correlated with genome size and growth rate.

The paper sequences 1000 SARS-CoV-2 genomes from India, revealing multiple circulating lineages, predominant A2a haplotype with D614G mutation, and geographic mutation clustering.

The paper introduces CoVa, a Python-based tool for analyzing SARS-CoV-2 genomes, identifying selection signatures, and defining sequence typing, with findings on geographic variation and mutation rates.

The paper uses laboratory evolution experiments to show that E. coli initiates constitutive stable DNA replication (cSDR) predominantly in a region ~0.6 Mb clockwise of oriC, and that genome inversions help resolve replication-transcription conflicts.

The paper investigates the early expression dynamics of horizontally transferred genes in E. coli, finding that H-NS binding correlates with silencing while some promoters exhibit high noise due to transcriptional interference.

This study uses RNA-Seq to show Rsd and 6S RNA regulate sigma factor activity and gene expression in E. coli across growth phases, revealing novel interactions and a mathematical model of transcriptional control.

The paper shows that RacR represses the ydaS toxin gene in the rac prophage of E. coli K12, preventing lethality upon its deletion.

This study examines mutations in E. coli during prolonged stationary-phase, finding increased genetic diversity and evidence of positive selection on regulatory mutations.

The paper investigates how second site mutations in cpxA and cyaA enhance kanamycin resistance in EF-G mutants by altering gene expression and regulatory networks.