Sumana Srinivasan

The Common Fund Data Ecosystem (CFDE)

The paper describes the Common Fund Data Ecosystem (CFDE), which integrates NIH Common Fund data resources to enable discovery, analysis, and collaboration across heterogeneous datasets.

The CFDE Workbench: Integrating Metadata and Processed Data from Common Fund Programs

The CFDE Workbench integrates metadata and processed data from Common Fund programs to enable FAIR and AI-ready cross-program knowledge discovery.

The molecular chronology of mammary epithelial cell fate switching

The paper maps the molecular programs enabling basal-to-luminal fate switching in mammary epithelial cells using time-resolved single-cell epigenetic and transcriptomic analyses.

Playbook Workflow Builder: Interactive Construction of Bioinformatics Workflows from a Network of Microservices

The paper introduces a web-based platform for building bioinformatics workflows using APIs, enabling hypothesis generation across multiple data sources.

Global pleiotropic effects in adaptively evolved Escherichia coli lacking CRP reveal molecular mechanisms that define growth physiology

This study shows how deleting CRP in E. coli leads to metabolic and proteomic changes that allow growth recovery through mutations and pathway re-allocation.

Global transcriptional regulators fine-tune the translational and metabolic machinery in Escherichia coli under anaerobic fermentation

The paper investigates the role of global transcriptional regulators in Escherichia coli under anaerobic fermentation, showing their impact on metabolic and translational efficiency and growth rates.