Placental pathology, circadian biology, and pathogenesis of spontaneous preterm birth: a pilot study of human placental gene expression profiling using a targeted HTG transcriptome panel
Guoli Zhou, Hanne Mette Hoffmann, Hidemi S. Yamamoto, Kathryn Woods, Melanie Adkins, Robert L. Barbieri, Raina Nakova Fichorova
This study identifies transcriptomic signatures in sPTB placentas, revealing suppressed metabolic and immune pathways, upregulated inflammatory and hypoxic pathways, and circadian dysregulation linked to preterm birth.
bioRxiv · Jun 29, 2026 · PreprintBioinformatics