Phospho 394Y LCK flow-cytometry readout predicts dasatinib sensitivity in paediatric T-cell acute lymphoblastic leukaemia
Alistair A. Poll, Yuzhe Shi, Kerstin Katharina Rauwolf, Beat C. Bornhauser, Andreas E. Kulozik, Jean‐Pierre Bourquin, Julie A. E. Irving, Frederik W. van Delft
The paper identifies phospho-LCK (pY394) as a biomarker for dasatinib sensitivity in paediatric T-ALL using flow-cytometry, showing strong correlation with drug response.
bioRxiv · Nov 4, 2025 · PreprintCancer Biology