Irene Maffucci

The paper designs DNA aptamers for Lyme disease detection by combining in silico selection using a Restricted Boltzmann Machine with experimental validation of selected sequences.

This paper evaluates three RNA 3D structure prediction tools on a dataset of ssDNA structures to assess their applicability to ssDNA and identify limitations in predicting complex motifs.

This paper selects and characterizes DNA aptamers targeting the Borrelia surface protein CspZ using cross-over SELEX and validates their binding affinity and specificity.

AptaMat is a matrix-based algorithm for comparing single-stranded oligonucleotides secondary structures, showing better discrimination than existing metrics.