Molecular BiologybioRxivPreprint
Excessive fluid shear stress-mediated Klf4 leads to arteriovenous pathogenesis
Kuheli Banerjee, Yanzhu Lin, Johannes Gahn…·Roxana Ola
This study shows that Smad4 loss in endothelial cells leads to AVM formation through flow-induced Klf4 activation and loss of arterial identity.
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