Gergana D. Dobreva

The paper investigates how FUS loss in fibroblasts affects transcriptional elongation and senescence in IPF, finding that reduced FUS levels increase Pol II activity and fibrosis-related gene expression.

This study examines the effects of RBM20-R636Q mutation on atrial electrophysiology and evaluates SGLT inhibitors as potential therapeutics for atrial remodeling and arrhythmias.

This study shows that loss of eEF1A2 in cardiomyocytes causes cardiomyopathy through proteostasis defects, and mTORC1 inhibition can reverse the condition.

This study identifies ferroptosis as a regulator of lymphatic vessel growth and regression, showing its role in development and injury response through metabolic and lipid pathway mechanisms.

The paper shows that nuclear miR-9 is required for chromatin features and promoter-super-enhancer looping during TGFB1-induced transcriptional activation.

This study identifies Gadlor1 and Gadlor2 as endothelial cell-derived lncRNAs that worsen cardiac remodeling through EV-mediated crosstalk with cardiomyocytes.

This study identifies Rnf20's role in regulating cardiac morphogenesis and function through endothelial mechanisms, revealing its impact on extracellular matrix dynamics and angiocrine signaling.

This study shows that Smad4 loss in endothelial cells leads to AVM formation through flow-induced Klf4 activation and loss of arterial identity.

The paper shows that HMGA2 induces DNA nicks required for nucleosome incorporation containing H2A.X, which is necessary for DNA demethylation and transcription initiation.