Excessive fluid shear stress-mediated Klf4 leads to arteriovenous pathogenesis
Kuheli Banerjee, Yanzhu Lin, Johannes Gahn, Purnima Gupta, Mariona Graupera, Gergana D. Dobreva, Martin Alexander Schwartz, Roxana Ola
This study shows that Smad4 loss in endothelial cells leads to AVM formation through flow-induced Klf4 activation and loss of arterial identity.
bioRxiv · Jul 4, 2022 · PreprintMolecular Biology