IL-2- and IL-4-dependent signaling play separate and sequential roles in the differentiation of GATA3-hi TH2 cells in vivo
Greta R. Webb, Caterina Carco, Shaiu-Choot Tang, Marie Sophie Fabre, Sotaro Ochiai, Abbie R. Larson, Jodie S. Chandler, Kerry L. Hilligan, Evelyn J. Hyde, Samuel I. Old, Olivier Lamiable, Franca Ronchese
This study shows IL-2 is needed for GATA3 upregulation in TH2 cells, while IL-4 promotes their proliferation and effector function in vivo.
bioRxiv · Mar 5, 2026 · PreprintImmunology