Eugen Pfeifer

The paper introduces tyPPing, a method for detecting and typing phage-plasmids with high accuracy, outperforming existing tools in sensitivity and scalability.

This study examines how antibiotic treatment affects the gut phageome, finding reduced diversity and increased virulent phage blooms, which may help restore bacterial diversity through kill-the-winner dynamics.

The paper identifies phage-plasmids as intermediaries facilitating genetic exchange between phages and plasmids, leading to the creation of novel elements and horizontal gene transfer.

The paper identifies 780 phage-plasmids across diverse bacterial phyla, groups them into 8 families based on gene repertoire similarity, and highlights their conserved phage genes and variable plasmid-like genes.