Errors in peptide synthesis are a source of discrepancies in Aβ42 studies
Karolina Matulewska-Sobczuk, Katja Bernfur, Dev Thacker, Johan Wallerstein, Elin Stemme, Alexander J. Dear, Nils Lindblom, Ewa A. Andrzejewska, Greta Šneiderienė, Tuomas P. J. Knowles, Gunnar K. Gouras, Ulf Olsson, Sara Snogerup Linse, Lei Ortigosa-Pascual
This study shows that sequence imperfections in synthetic Aβ42 peptides cause differences in aggregation behavior compared to recombinant Aβ42.
bioRxiv · Jul 31, 2026 · PreprintBiochemistry