Abhinav K. Jain

This study links low stool valerate to CAR T-cell dysfunction in B-cell lymphoma and shows valerate supplementation improves CAR T function.

This study identifies KDM5D on the Y chromosome as a suppressor of CD8+ T cell antitumor immunity in males, linking it to TCR and cholesterol-exhaustion programs.

The paper examines how aging affects antigen-specific memory CD8+ T cells in EBV infection, finding distinct aging trajectories with changes in gene expression and TCR diversity.

Aging primarily impairs the CD8+ T cell VZV vaccine response, while effective VZV vaccination in older adults induces antigen-specific Th17 CD4+ T cells to compensate for aging defects.

The paper investigates the prevalence and association of RFC1 tandem nucleotide repeat expansions with neurodegenerative diseases in an Indian cohort.

This study analyzes Indian genetic variations in the kinome to identify sequence, structural, and pharmacogenomic differences compared to global datasets, highlighting implications for drug safety and adverse reactions.

The paper analyzes intra-host Single Nucleotide Variations (iSNVs) in SARS-CoV-2 genomes across multiple time points and regions, finding that many iSNVs later become population-level variants and some may contribute to immune escape.

The paper identifies a novel 5,296 bp deletion in the BTK gene in an Indian family with X-linked agammaglobulinemia through whole genome sequencing and carrier screening.

The paper analyzes SARS-CoV-2 isolates from Kerala, India, identifying 166 unique variants, including 4 novel ones, and reports on their genetic epidemiology and potential impact on diagnostics.

This study evaluates the COVIDSeq protocol for SARS-CoV-2 detection and genetic epidemiology, showing high concordance with RT-PCR and identifying novel variants and lineages.

This study sequenced SARS-CoV-2 genomes from Andhra Pradesh, identifying 564 variants including 15 novel ones and 4 associated with increased infectivity.

The paper analyzes genomic variants in SARS-CoV-2 isolates from India and their potential impact on molecular diagnostic assays.