Author

E. Renee Matthews

The University of Texas Medical Branch at GalvestonORCID 0000-0002-4603-8827Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 2 Research Focus:GWAS / association mapping· 2 Assay:ATAC-seq· 1 Approach:benchmark study· 1

Frequent Co-Authors

Michelle C. WardiD· 4 shared Sayan PauliD· 3 shared Alyssa R. Bogar· 2 shared José A. Gutiérrez· 2 shared Omar D. JohnsoniD· 2 shared John D. HurleyiD· 1 shared José A GutiérreziD· 1 shared Jose A. Gutierrez· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersGenomics

Michelle C. WardORCID

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4 papers

Recent·Most cited

GenomicsbioRxivPreprintFeb 15, 2026

Conserved RNA-protein modules link early anthracycline responses to atrial fibrillation risk

Omar D. Johnson, E. Renee Matthews, Sayan Paul…·Michelle C. Ward

The paper identifies RNA-protein modules linked to anthracycline-induced cardiotoxicity and atrial fibrillation risk through multi-omics integration.

DOI 10.64898/2026.02.15.706019

humanproteomics

𝕏 PostBluesky

GenomicsG3 Genes Genomes GeneticsPeer-reviewedJan 16, 2026

Topoisomerase II inhibitors CX-5461 and Doxorubicin differ in their cardiotoxicity profiles

Sayan Paul, Jose A. Gutierrez, Alyssa R. Bogar…·Michelle C. Ward

This study compares the cardiotoxicity of CX-5461 and Doxorubicin in iPSC-derived cardiomyocytes, finding CX is less cytotoxic and induces fewer gene expression changes.

2 citationstop 3%

humanbulk RNA-seq

𝕏 PostBluesky

GenomicsPLoS GeneticsPeer-reviewedOct 14, 2025

Anthracyclines induce global changes in cardiomyocyte chromatin accessibility that overlap with cardiovascular disease loci

E. Renee Matthews, Raodatullah O. Abodunrin, John D. Hurley…·Michelle C. Ward

This study shows anthracyclines alter chromatin accessibility in cardiomyocytes, overlapping with cardiovascular disease risk loci.

2 citations

𝕏 PostBluesky

GenomicsPLoS GeneticsPeer-reviewedFeb 28, 2024

Anthracycline-induced cardiotoxicity associates with a shared gene expression response signature to TOP2-inhibiting breast cancer drugs in cardiomyocytes

E. Renee Matthews, Omar D. Johnson, K Horn…·Michelle C. Ward

The paper investigates the shared gene expression response to TOP2-inhibiting breast cancer drugs in cardiomyocytes and identifies genetic factors associated with inter-individual variation in cardiotoxicity.

12 citations

humanbulk RNA-seq

𝕏 PostBluesky