Maternal IL-17A administration fails to disrupt fetal cortical lamination in the absence of maternal microbes
Izan Chalen, Selena Wang, Rafael Gonzalez-Ricon, Ashley M. Otero, Fernando J. Rigal, Alexander Byrne, Shakirat Adetunji, Catherine Best-Popescu, Adrienne M. Antonson
This study shows that maternal IL-17A administration to germ-free mice does not disrupt fetal cortical lamination, suggesting IL-17A alone is insufficient to cause brain abnormalities without microbial signals.
Discover Neuroscience · Jun 7, 2026Peer-reviewedNeuroscience