Jeffrey N. Savas

Extracellular neuroligin-ICAM5 coupling drives dendritic growth via actin remodeling

This study identifies ICAM5 as a neuroligin interactor that drives dendritic growth through actin remodeling by sustaining PAK-Cofilin signaling.

A pathogenic AMPAR mutation disrupts hippocampal synapse maturation and homeostasis

This study shows that a pathogenic AMPAR mutation impairs hippocampal synapse maturation and leads to metabolic adaptations over time.

Brain Landscape In Situ Crosslinking Mass Spectrometry (BLIS-XL-MS) Enables Global Analysis of Protein Structural Remodeling in the Brain

BLIS-XL-MS enables proteome-wide analysis of structural remodeling in brain tissue by combining experimental and computational methods to study protein conformational changes in neurodevelopmental disorders.

Heat-shock pathway activation by TRC051384 protects spiral ganglion neurons from noise-induced hearing loss

TRC051384, an Hsf1 activator, protects spiral ganglion neurons from noise-induced hearing loss by restoring proteasome function and preserving synapse density.

Single-cell transcriptional landscape of muscle-derived stem/progenitor cells reveals hallmarks of aging and rejuvenation

The paper profiles murine muscle-derived stem/progenitor cells across age groups using single-cell transcriptomics and proteomics, revealing a transcriptional continuum of maturation and aging-related changes.

Response dynamics of discrete subiculum->retrosplenial cortex projections underlying trace fear conditioning

The paper investigates how specific subiculum-to-retrosplenial cortex projections contribute to trace fear conditioning by analyzing their activity patterns during memory formation and recall.

Ubiquitin Proteasome System Components, RAD23A and USP13, Modulate TDP-43 Solubility and Neuronal Toxicity

This study identifies RAD23A and USP13 as modifier genes that enhance TDP-43 solubility and reduce neuronal toxicity in ALS models.

Global Analysis of Aggregation Determinants in Small Protein Domains

The paper quantifies aggregation in small protein domains under stress and uses machine learning to identify predictors, improving aggregation prediction models.

Influenza A virus infection during pregnancy increases transfer of maternal bloodborne molecules to fetal tissues

This study shows that influenza A virus infection during pregnancy increases the transfer of maternal bloodborne molecules to fetal tissues, potentially activating proinflammatory pathways in fetal brain regions.

Neurofilament accumulation disrupts autophagy in giant axonal neuropathy

This paper shows that neurofilament accumulation in GAN disrupts autophagy through impaired organelle distribution and sequestration of 14-3-3, affecting TFEB localization.

Pro-cognitive reshaping of neuronal dynamics by a human CSF-based factor

This study identifies a soluble synaptic protein, 2{delta}-1, reduced in schizophrenia CSF, which enhances neuronal network dynamics and cognitive function when administered to a mouse model.

The ALS-associated co-chaperone DNAJC7 mediates neuroprotection against proteotoxic stress by modulating HSF1 activity

This study identifies DNAJC7 as a mediator of neuroprotection in ALS by modulating HSF1 activity and shows that HSF1 expression can rescue proteotoxic stress in mutant DNAJC7 neurons.

Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in Alzheimer's disease models

The paper discovers that levetiracetam prevents Aβ42 production by modulating synaptic vesicle cycling, altering APP localization, and favoring non-amyloidogenic processing in Alzheimer's disease models.

Isotope Encoded Chemical Imaging Identifies Amyloid Plaque Age Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity

This paper uses isotope-encoded mass spectrometry imaging and single plaque transcriptomics to track Aβ plaque maturation and its impact on synaptic function and toxicity in Alzheimer's disease.

Do perineuronal nets stabilize the engram of a synaptic circuit?

The paper investigates whether perineuronal nets (PNNs) stabilize synaptic circuits and engram formation through high-resolution imaging and experimental approaches.

Reduction of RAD23A extends lifespan and mitigates pathology in TDP-43 mice

This study shows that reducing RAD23A in TDP-43 mice improves survival, behavior, and reduces TDP-43 pathology and transcriptomic alterations.

Keratinocyte-derived exosomes in painful diabetic neuropathy

This study investigates keratinocyte-derived exosomes in a mouse model of painful diabetic neuropathy, finding differences in their molecular content and showing retrograde trafficking to DRG neurons.

Chemical imaging signatures delineate heterogeneous amyloid plaque populations across the Alzheimers disease spectrum

This study uses chemical imaging and deep learning to identify distinct amyloid plaque subtypes in Alzheimer's disease, revealing differences in Aβ composition and associations with disease progression.

A pathogenic missense mutation in kainate receptors elevates dendritic excitability and synaptic integration through dysregulation of SK channels

This study investigates a missense mutation in the GRIK2 gene, showing it disrupts SK channel function, leading to increased dendritic excitability and synaptic integration in hippocampal neurons.

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

The paper isolates and analyzes amyloid fibrils from AD brains and models to identify proteins associated with fibril formation and toxicity, finding new proteins and validating their roles.

Neuron-specific protein expression at striatal excitatory synapses

The paper identifies neuron-type-specific synaptic protein isoform expression in striatal spiny projection neurons and shows its impact on synapse diversity and dysfunction.

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

This study identifies PRRT2 as a key hub in an epilepsy network disrupted by 16p11.2 duplication and shows its correction rescues multiple neuropsychiatric and seizure-related phenotypes in mice.

Brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning

The paper develops DELTA, a method to measure brain-wide synaptic protein turnover at single-synapse resolution, revealing localized plasticity in hippocampal CA1 during learning.

Relapse-like behavior and nAChR sensitization following intermittent access nicotine self-administration

This study investigates the effects of intermittent nicotine self-administration in rats, finding increased nicotine seeking and neurobiological changes compared to continuous access.

Sex-Dependent Effects of Chronic Microdrive Implantation on Acquisition of Trace Eyeblink Conditioning

This study investigates sex-dependent effects of chronic microdrive implantation on trace eyeblink conditioning in mice, finding that males learned faster than females with implants, but not with dummy implants.

Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer

The paper identifies IgSF8 as a regulator of hippocampal CA3 microcircuit development by analyzing cell-surface protein composition and synaptic interactions.

Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense Mediated Decay as Modifiers of ALS C9orf72 Toxicity

The paper identifies eRF1 and NMD as modifiers of C9orf72 repeat expansion toxicity by analyzing nucleocytoplasmic proteomic changes in ALS/FTD.

CNTNAP2 ectodomain, detected in neuronal and CSF sheddomes, modulates Ca2+ dynamics and network synchrony

Altered protein quality control contributes to noise-induced hearing loss

The paper investigates how noise exposure alters the cochlear proteome in mice, identifying proteostasis responses and proteins involved in regeneration and mitochondrial dysfunction in noise-induced hearing loss.

Amyloid accumulation drives proteome-wide alterations in mouse models of Alzheimers disease like pathology

The paper identifies proteome-wide changes in mouse models of Alzheimer's disease, highlighting ApoE dysregulation and synaptic protein loss.