Supression of Perforin-like Protein pores inhibit Plasmodium multistage-growth, transmission and erythrocyte senescence
Swati Garg, Abhishek Shivappagowdar, Rahul Singh Hada, Rajagopal Ayana, Chandramohan Bathula, Subhabrata Sen, Inderjeet Kalia, Soumya Pati, Agam Prasad Singh, Shailja Singh
This paper identifies PMD as a conserved region of Plasmodium perforin-like proteins that forms pores in erythrocytes, leading to anemia, and shows that anti-PMD inhibitors block parasite growth and transmission across multiple stages.
bioRxiv · Sep 5, 2019 · PreprintMolecular Biology