Rachael B. Chanin

The paper shows that the K5 capsular polysaccharide of E. coli Nissle 1917 sensitizes it to thioridazine and related antipsychotics, revealing CPS as a vulnerability under non-antibiotic drug pressure.

The paper uses long-read metagenomics to study prophage integration dynamics in gut microbiota, finding dynamic phage-host interactions and a new class of phages.

The paper develops a method to detect invertons in gut microbiome metagenomic data and finds associations between inverton dynamics and intestinal colonization and surface adhesion.