Deconvolution of multiplexed peptidoform mass spectra enables high-resolution profiling of complex protein modification patterns
Zhiyuan Cheng, Linhui Zhai, Li Yu, Kaifeng Chen, Wensi Zhao, Minjia Tan, Yan Hong Huang Fu
The paper introduces PTMdecoder, a tool for deconvoluting multiplexed mass spectra to identify and quantify isobaric modification peptidoforms with high sensitivity and accuracy.
bioRxiv · May 24, 2025 · PreprintBioinformatics