Tau aggregates are RNA-protein assemblies that mis-localize multiple nuclear speckle components
Evan Lester, Felicia K. Ooi, Nadine Bakkar, Jacob I. Ayers, Amanda L. Woerman, Joshua Wheeler, Robert P. Bowser, George A. Carlson, Stanley B. Prusiner, Roy Parker
The paper shows that tau aggregates in cells and brains contain RNA and alter nuclear speckle components, affecting pre-mRNA splicing.
Neuron · Apr 13, 2021Peer-reviewedMolecular Biology