Author

Evan Lester

University of Colorado BoulderORCID 0000-0002-0486-0361Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Roy ParkeriD· 4 shared James Pratt· 2 shared Joshua WheeleriD· 2 shared Kathleen L. McCanniD· 2 shared Meaghan Van AlstyneiD· 2 shared Aaron M. JohnsoniD· 1 shared Alicia Ann CutleriD· 1 shared Amanda L. WoermaniD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersNeuroscience

Roy ParkerORCID

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4 papers

Recent·Most cited

Nuclear tau aggregates inhibit RNA export and form by secondary seeding from cytosolic tau aggregates.

Carolyn J. Decker, Kathleen L. McCann, Evan Lester, James Pratt, Meaghan Van Alstyne, Yuchen Wang, Roy Parker

bioRxiv · Feb 18, 2026 · PreprintNeuroscience

Cytosolic condensates enriched in polyserine repeats are preferred sites of tau fiber propagation

Evan Lester, Meaghan Van Alstyne, Kathleen L. McCann, Spoorthy Reddy, Li Yi Cheng, Jeff Kuo, James Pratt, Roy Parker

The paper shows polyserine repeats in SRRM2 and PNN recruit to tau aggregates and promote tau fiber propagation in cytoplasmic condensates.

bioRxiv · Sep 22, 2022 · PreprintNeuroscience

RNA-BINDING PROTEINS DIRECT MYOGENIC CELL FATE DECISIONS

Joshua Wheeler, Oscar N. Whitney, Thomas Orion Vogler, Eric D. Nguyen, Bradley T. Pawlikowski, Evan Lester, Alicia Ann Cutler, Tiffany L. Elston, Nicole Dalla Betta, Kevin R. Parker, Kathryn E. Yost, Hannes S. Vogel, Thomas A. Rando, Howard Y. Chang, Aaron M. Johnson, , Bradley B. Olwin

The paper identifies Hnrnpa2b1 as a key RBP regulating myogenic differentiation through post-transcriptional control in skeletal muscle regeneration.

eLife · May 23, 2022Peer-reviewedMolecular Biology

Tau aggregates are RNA-protein assemblies that mis-localize multiple nuclear speckle components

Evan Lester, Felicia K. Ooi, Nadine Bakkar, Jacob I. Ayers, Amanda L. Woerman, Joshua Wheeler, Robert P. Bowser, George A. Carlson, Stanley B. Prusiner, Roy Parker

The paper shows that tau aggregates in cells and brains contain RNA and alter nuclear speckle components, affecting pre-mRNA splicing.

Neuron · Apr 13, 2021Peer-reviewedMolecular Biology