Robert P. Bowser

The paper compares TDP-43's transcriptional and splicing effects in muscle and neuronal cells, showing tissue-specific roles in disease.

The paper examines whether blood-spinal cord barrier breakdown correlates with motor neuron loss and TDP-43 proteinopathy in ALS, finding they have distinct regional patterns.

The paper shows that tau aggregates in cells and brains contain RNA and alter nuclear speckle components, affecting pre-mRNA splicing.

The paper identifies TDP-43 proteinopathy's impact on mRNA ribosome association, highlighting Dlp/GPC6 as a novel target in ALS.

This study examines C9orf72 ALS/FTD patient-derived iPSC-microglia mono-cultures, finding they form RNA foci, have reduced C9orf72 protein, and show endosomal-lysosomal dysfunction, but no significant microglial-enriched gene expression differences.

This study identifies RBM45's role in forming nuclear inclusions during stress and in neurodegenerative diseases, linking it to nuclear stress bodies and disease-specific pathology.

The paper uses unsupervised machine learning to identify three molecular subtypes in ALS cortex samples, associated with oxidative stress, retrotransposon activation, and glial activation.

The paper shows that increased glycolysis is neuroprotective in ALS by improving locomotion and lifespan in Drosophila models through glucose transporter and PFK overexpression.